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phenobarbital will reduce the extent or effect of ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers might minimize partiaprevir and ritonavir stages, and thus lowered efficacy of Viekira Pakphenobarbital decreases amounts of vandetanib by affecting h